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The tumor microenvironment and immune targeting therapy in pediatric renal tumors

Hont, Amy B; Dumont, Benoit; Sutton, Kathryn S; Anderson, John; Kentsis, Alex; Drost, Jarno; Hong, Andrew L; (2022) The tumor microenvironment and immune targeting therapy in pediatric renal tumors. Pediatric Blood & Cancer , Article e30110. 10.1002/pbc.30110. (In press). Green open access

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Abstract

This review highlights the role of several immunomodulating elements contributing to the tumor microenvironment of various pediatric renal tumors including Wilms tumor. The roles of innate and adaptive immune cells in renal tumors are summarized as well as immunomodulatory cytokines and other proteins. The expression and the predictive role of checkpoint modulators like PD-L1 and immunomodulating proteins like glypican-3, B7-H3, COX-2 are highlighted with a translational view toward potential therapeutic innovations. We further discuss the current state of preclinical models in advancing this field of study. Finally, examples of clinical trials of immunomodulating strategies such as monoclonal antibodies and chimeric antigen receptor T (CAR-T) cells for relapsed/refractory/progressive pediatric renal tumors are described.

Type: Article
Title: The tumor microenvironment and immune targeting therapy in pediatric renal tumors
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/pbc.30110
Publisher version: https://doi.org/10.1002/pbc.30110
Language: English
Additional information: © 2022 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Keywords: immunotherapy, pediatric renal tumor, tumor microenvironment
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10162472
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