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The importance of inflammation control for the treatment of chronic diabetic wounds

Worsley, Anna L; Lui, Dennis H; Ntow-Boahene, Winnie; Song, Wenhui; Good, Liam; Tsui, Janice; (2022) The importance of inflammation control for the treatment of chronic diabetic wounds. International Wound Journal 10.1111/iwj.14048. (In press). Green open access

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Abstract

Diabetic chronic wounds cause massive levels of patient suffering and economic problems worldwide. The state of chronic inflammation arises in response to a complex combination of diabetes mellitus-related pathophysiologies. Advanced treatment options are available; however, many wounds still fail to heal, exacerbating morbidity and mortality. This review describes the chronic inflammation pathophysiologies in diabetic ulcers and treatment options that may help address this dysfunction either directly or indirectly. We suggest that treatments to reduce inflammation within these complex wounds may help trigger healing.

Type: Article
Title: The importance of inflammation control for the treatment of chronic diabetic wounds
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/iwj.14048
Publisher version: https://doi.org/10.1111/iwj.14048
Language: English
Additional information: © 2022 The Authors. International Wound Journal published by Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: chronic wounds, diabetes, diabetic ulcers, inflammation, wound healing
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10162469
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