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Comparing ARIA-E severity scales and effects of treatment management thresholds

Klein, Gregory; Scelsi, Marzia A; Barakos, Jerome; Fiebach, Jochen B; Bracoud, Luc; Suhy, Joyce; Delmar, Paul; ... Purcell, Derk; + view all (2022) Comparing ARIA-E severity scales and effects of treatment management thresholds. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring , 14 (1) , Article e12376. 10.1002/dad2.12376. Green open access

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Abstract

INTRODUCTION: Amyloid-related imaging abnormalities-edema (ARIA-E) is associated with anti-amyloid beta monoclonal antibody treatment. ARIA-E severity may be assessed using the Barkhof Grand Total Scale (BGTS) or the 3- or 5-point Severity Scales of ARIA-E (SSAE-3/SSAE-5). We assessed inter- and intra-reader correlations between SSAE-3/5 and BGTS. METHODS: Magnetic resonance imaging scans were collected from 75 participants in the SCarlet RoAD and Marguerite RoAD studies. Three neuroradiologists reviewed scans at baseline and at follow-up. Concordance in dichotomized ARIA-E ratings was assessed for a range of BGTS thresholds. RESULTS: SSAE-3/5 scores correlated with BGTS scores, with high inter-reader intraclass correlation coefficients across all scales. There was high agreement in dichotomized ratings for SSAE-3 > 1 versus BGTS > 3 for all readers (accuracy 0.85-0.93) and between pairs of readers. DISCUSSION: SSAE-3/5 showed high degrees of correlation with BGTS, potentially allowing seamless transition from the BGTS to SSAE-3/5 for ARIA-E management.

Type: Article
Title: Comparing ARIA-E severity scales and effects of treatment management thresholds
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/dad2.12376
Publisher version: https://doi.org/10.1002/dad2.12376
Language: English
Additional information: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. See: http://creativecommons.org/licenses/by-nc/4.0/
Keywords: ARIA‐E, Alzheimer's disease, Barkhof Grand Total Scale, SSAE, Severity Scale of ARIA‐E, amyloid‐related imaging abnormalities, correlation, edema, magnetic resonance imaging
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery.ucl.ac.uk/id/eprint/10162139
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