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Similarities in the histological mouse model of early herpes simplex retinopathy with punctate inner choroidopathy and Ebola virus disease retinopathy

Steptoe, Paul J; Guly, Catherine M; Dick, Andrew D; (2022) Similarities in the histological mouse model of early herpes simplex retinopathy with punctate inner choroidopathy and Ebola virus disease retinopathy. European Journal of Ophthalmology 10.1177/11206721221144337. (In press). Green open access

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Abstract

ABSTRACT PURPOSE: To highlight similarities between the cross-sectional retinal lesion appearance in a patient with punctate inner choroidopathy (PIC), Ebola virus disease (EVD) retinopathy and the von Szily mouse model of herpes simplex virus type 1 (HSV) retinopathy. METHODS: Case report and cross-sectional retinal lesion comparison. RESULTS: Whilst phenotypically different on colour imaging, a near-identical lesion appearance on optical coherence tomography, characterised by a focal photoreceptor loss and distinctive V-shaped collapse of the overlying retinal layers, was observed in both PIC and EVD retinopathy. This mirrored the early histological appearance of the neuronally transmitted HSV retinopathy in a mouse model. CONCLUSIONS: Given the occurrence of this phenotypic appearance has been demonstrated in an animal model where the viral pathophysiological mechanism is known, together with its observation in EVD retinopathy with a shared, hypothesised neurotropic retinal pathogenesis, the potential of a common pathophysiology accounting for the appearance in PIC lesions is a possibility which may provide a potential avenue for future research.

Type: Article
Title: Similarities in the histological mouse model of early herpes simplex retinopathy with punctate inner choroidopathy and Ebola virus disease retinopathy
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/11206721221144337
Publisher version: https://doi.org/10.1177/11206721221144337
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Von Szily model, punctate inner choroidopathy, herpes simplex virus retinopathy, Ebola virus disease, neurotropic retinitis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10162005
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