Van Den Hout, Arie;
Pan, Shengning;
(2023)
Bivariate joint models for survival and change of cognitive function.
Statistical Methods in Medical Research
, 32
(3)
pp. 474-492.
10.1177/096228022211463.
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Abstract
Changes in cognitive function over time are of interest in ageing research. A joint model is constructed to investigate. Generally, cognitive function is measured through more than one test, and the test scores are integers. The aim is to investigate two test scores and use an extension of a bivariate binomial distribution to define a new joint model. This bivariate distribution model the correlation between the two test scores. To deal with attrition due to death, the Weibull hazard model and the Gompertz hazard model are used. A shared random-effects model is constructed, and the random effects are assumed to follow a bivariate normal distribution. It is shown how to incorporate random effects that link the bivariate longitudinal model and the survival model. The joint model is applied to the English Longitudinal Study of Ageing data.
| Type: | Article |
|---|---|
| Title: | Bivariate joint models for survival and change of cognitive function |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/096228022211463 |
| Publisher version: | https://doi.org/10.1177/096228022211463 |
| Language: | English |
| Additional information: | This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page |
| Keywords: | Joint model, bivariate binomial distribution, cognitive function, survival analysis, shared random-effects model |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Statistical Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10161985 |
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