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Including diverse and admixed populations in genetic epidemiology research

Caliebe, Amke; Tekola-Ayele, Fasil; Darst, Burcu F; Wang, Xuexia; Song, Yeunjoo E; Gui, Jiang; Sebro, Ronnie A; ... Dube, Marie-Pierre; + view all (2022) Including diverse and admixed populations in genetic epidemiology research. Genetic Epidemiology , 46 (7) pp. 347-371. 10.1002/gepi.22492. Green open access

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Abstract

The inclusion of ancestrally diverse participants in genetic studies can lead to new discoveries and is important to ensure equitable health care benefit from research advances. Here, members of the Ethical, Legal, Social, Implications (ELSI) committee of the International Genetic Epidemiology Society (IGES) offer perspectives on methods and analysis tools for the conduct of inclusive genetic epidemiology research, with a focus on admixed and ancestrally diverse populations in support of reproducible research practices. We emphasize the importance of distinguishing socially defined population categorizations from genetic ancestry in the design, analysis, reporting, and interpretation of genetic epidemiology research findings. Finally, we discuss the current state of genomic resources used in genetic association studies, functional interpretation, and clinical and public health translation of genomic findings with respect to diverse populations.

Type: Article
Title: Including diverse and admixed populations in genetic epidemiology research
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/gepi.22492
Publisher version: https://doi.org/10.1002/gepi.22492
Language: English
Keywords: © 2022 The Authors. Genetic Epidemiology published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/10161940
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