Kupferschmidt, David A;
Cummings, Kirstie A;
Joffe, Max E;
MacAskill, Andrew;
Malik, Ruchi;
Sanchez-Bellot, Candela;
Tejeda, Hugo A;
(2022)
Prefrontal Interneurons: Populations, Pathways, and Plasticity Supporting Typical and Disordered Cognition in Rodent Models.
The Journal of Neuroscience
, 42
(45)
pp. 8468-8476.
10.1523/JNEUROSCI.1136-22.2022.
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Abstract
Prefrontal cortex (PFC) inhibitory microcircuits regulate the gain and timing of pyramidal neuron firing, coordinate neural ensemble interactions, and gate local and long-range neural communication to support adaptive cognition and contextually tuned behavior. Accordingly, perturbations of PFC inhibitory microcircuits are thought to underlie dysregulated cognition and behavior in numerous psychiatric diseases and relevant animal models. This review, based on a Mini-Symposium presented at the 2022 Society for Neuroscience Meeting, highlights recent studies providing novel insights into: (1) discrete medial PFC (mPFC) interneuron populations in the mouse brain; (2) mPFC interneuron connections with, and regulation of, long-range mPFC afferents; and (3) circuit-specific plasticity of mPFC interneurons. The contributions of such populations, pathways, and plasticity to rodent cognition are discussed in the context of stress, reward, motivational conflict, and genetic mutations relevant to psychiatric disease.
| Type: | Article |
|---|---|
| Title: | Prefrontal Interneurons: Populations, Pathways, and Plasticity Supporting Typical and Disordered Cognition in Rodent Models |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1523/JNEUROSCI.1136-22.2022 |
| Publisher version: | https://doi.org/10.1523/JNEUROSCI.1136-22.2022 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | BASOLATERAL AMYGDALA, cognition, CORTICAL INTERNEURONS, EXCITATORY SYNAPSES, FAST-SPIKING INTERNEURON, FEEDFORWARD INHIBITION, GABAERGIC INTERNEURONS, inhibitory neurons, Life Sciences & Biomedicine, LONG-TERM POTENTIATION, microcircuits, MOUSE MODEL, Neurosciences, Neurosciences & Neurology, PARVALBUMIN INTERNEURONS, plasticity, prefrontal cortex, Science & Technology, TRANSCRIPTOMIC CELL-TYPES |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10161862 |
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