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Towards a Fully Implantable Closed-Loop Opto-Electro Stimulation Interface for Motor Neuron Disease Treatment

Liu, F; Jiang, D; Demosthenous, A; (2022) Towards a Fully Implantable Closed-Loop Opto-Electro Stimulation Interface for Motor Neuron Disease Treatment. In: Proceedings - 2022 IEEE International Symposium on Circuits and Systems (ISCAS). (pp. pp. 947-950). IEEE: Austin, TX, USA. Green open access

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Abstract

This paper presents a fully-implantable closed-loop opto-electro stimulation interface for motor neuron disease studies, designed for experiments with freely moving rodents. A low power consumption Bluetooth data link is used to wirelessly control 64 opto-electro stimulation channels and receive neural recording data. The implant is powered by a wirelessly rechargeable lithium-ion battery, which can support 2.5 hours continuous operation with a stimulation output up to 10 mA. The battery is recharged using a QI standard wireless inductive power link, which can deliver >100mW power at a distance of 2 cm. The total size of the implant system is 29 mm × 20 mm × 13 mm. Its performance is compared with the state-of-the-art.

Type: Proceedings paper
Title: Towards a Fully Implantable Closed-Loop Opto-Electro Stimulation Interface for Motor Neuron Disease Treatment
Event: 2022 IEEE International Symposium on Circuits and Systems (ISCAS)
Dates: 27 May 2022 - 1 Jun 2022
ISBN-13: 9781665484855
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/ISCAS48785.2022.9937349
Publisher version: https://doi.org/10.1109/ISCAS48785.2022.9937349
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Electrophysiological recording, integrated circuits, motor neurone disease, optogenetics, opto-electro stimulation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10161569
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