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Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

Baenke, Franziska; Peck, Barrie; Miess, Heike; Schulze, Almut; (2013) Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development. Disease Models & Mechanisms , 6 (6) pp. 1353-1363. 10.1242/dmm.011338. Green open access

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Abstract

An increased rate of lipid synthesis in cancerous tissues has long been recognised as an important aspect of the rewired metabolism of transformed cells. However, the contribution of lipids to cellular transformation, tumour development and tumour progression, as well as their potential role in facilitating the spread of cancerous cells to secondary sites, are not yet fully understood. In this article, we review the recent findings that support the importance of lipid synthesis and metabolism in tumorigenesis. Specifically, we explore the role of aberrant lipid biosynthesis in cancer cell migration and invasion, and in the induction of tumour angiogenesis. These processes are crucial for the dissemination of tumour cells and formation of metastases, which constitute the main cause of cancer mortality.

Type: Article
Title: Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development
Open access status: An open access version is available from UCL Discovery
DOI: 10.1242/dmm.011338
Publisher version: https://doi.org/10.1242/dmm.011338
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL SLASH
UCL > Provost and Vice Provost Offices > UCL SLASH > Faculty of S&HS
UCL > Provost and Vice Provost Offices > UCL SLASH > Faculty of S&HS > Dept of Economics
URI: https://discovery.ucl.ac.uk/id/eprint/10161563
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