Wan, Elizabeth R;
Elands, Sophie A;
Walsh, Stephen B;
(2023)
Post-transplantation cutaneous and renal Aspergillus infection.
International Journal of Infectious Diseases
, 127
pp. 23-25.
10.1016/j.ijid.2022.11.034.
Preview |
Text
1-s2.0-S1201971222006294-main (1).pdf Download (1MB) | Preview |
Abstract
A 68-year old renal transplant recipient suffered multiple complications following initial good graft function from a deceased-donor transplant. Late in the first week he was oliguric with haematuria; the graft failed in week 2 following development of a haematoma from rupture of a renal artery aneurysm. He had a recurrent bleed from the internal iliac graft site and subsequently developed painful dark patches on his leg, distal to where the transplant had been. Histology from the explanted graft and skin biopsies demonstrated Aspergillus flavus; this was also grown in culture of the external iliac artery tissue. Systemic aspergillosis is rare but well recognised, especially in the immunocompromised. Presentations include mycotic aneurysms and secondary cutaneous aspergillosis from haematogenous spread. Diagnosis requires confirmation by histology or direct culture, but a high beta-glucan concentration and positive galactomannan antigen can suggest invasive fungal infection in the early stages of the disease. Cases should be managed with systemic antifungals and involvement of local microbiology services; unfortunately, prognosis is poor.
Archive Staff Only
 |
View Item |
