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Serotype 1 pneumococcus: epidemiology, genomics, and disease mechanisms

Chaguza, Chrispin; Yang, Marie; Jacques, Laura C; Bentley, Stephen D; Kadioglu, Aras; (2022) Serotype 1 pneumococcus: epidemiology, genomics, and disease mechanisms. Trends in Microbiology , 30 (6) pp. 581-592. 10.1016/j.tim.2021.11.007. Green open access

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Abstract

Streptococcus pneumoniae (the 'pneumococcus') is a significant cause of morbidity and mortality worldwide, causing life-threatening diseases such as pneumonia, bacteraemia, and meningitis, with an annual death burden of over one million. Discovered over a century ago, pneumococcal serotype 1 (S1) is a significant cause of these life-threatening diseases. Our understanding of the epidemiology and biology of pneumococcal S1 has significantly improved over the past two decades, informing the development of preventative and surveillance strategies. However, many questions remain unanswered. Here, we review the current state of knowledge of pneumococcal S1, with a special emphasis on clinical epidemiology, genomics, and disease mechanisms.

Type: Article
Title: Serotype 1 pneumococcus: epidemiology, genomics, and disease mechanisms
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tim.2021.11.007
Publisher version: https://doi.org/10.1016/j.tim.2021.11.007
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Pneumococcus, serotype 1, genomics, outbreaks, invasiveness, virulence
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10160997
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