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Nitrous oxide-induced motor-predominant axonal peripheral neuropathy: A phenotype distinct from isolated vitamin B12 deficiency

Lee, Manon; Abbas, Ahmed; Lee, Omay; Record, Christopher J; Moodley, Kuven K; Nirmalananthan, Niranjanan; (2021) Nitrous oxide-induced motor-predominant axonal peripheral neuropathy: A phenotype distinct from isolated vitamin B12 deficiency. Journal of the Neurological Sciences , 424 , Article 117390. 10.1016/j.jns.2021.117390. Green open access

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Abstract

Highlights: N2O toxicity and B12 deficiency both cause a sensory predominant myeloneuropathy. N2O abuse may also lead to a selectively severe motor axonal peripheral neuropathy. This motor neuropathy phenotype may be related to N2O direct neural toxicity. In-vivo measures of motor axonal dysfunction are more pronounced in N2O abuse.

Type: Article
Title: Nitrous oxide-induced motor-predominant axonal peripheral neuropathy: A phenotype distinct from isolated vitamin B12 deficiency
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jns.2021.117390
Publisher version: https://doi.org/10.1016/j.jns.2021.117390
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Nitrous oxide, Vitamin B12, Motor, Sensory, Axonal, Neuropathy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10160911
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