George, Peter M;
Reed, Anna;
Desai, Sujal R;
Devaraj, Anand;
Faiez, Tasnim Shahridan;
Laverty, Sarah;
Kanwal, Amama;
... Singanayagam, Aran; + view all
(2022)
A persistent neutrophil-associated immune signature characterizes post-COVID-19 pulmonary sequelae.
Science Translational Medicine
, 14
(671)
, Article eabo5795. 10.1126/scitranslmed.abo5795.
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Abstract
Interstitial lung disease and associated fibrosis occur in a proportion of individuals who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through unknown mechanisms. We studied individuals with severe coronavirus disease 2019 (COVID-19) after recovery from acute illness. Individuals with evidence of interstitial lung changes at 3 to 6 months after recovery had an up-regulated neutrophil-associated immune signature including increased chemokines, proteases, and markers of neutrophil extracellular traps that were detectable in the blood. Similar pathways were enriched in the upper airway with a concomitant increase in antiviral type I interferon signaling. Interaction analysis of the peripheral phosphoproteome identified enriched kinases critical for neutrophil inflammatory pathways. Evaluation of these individuals at 12 months after recovery indicated that a subset of the individuals had not yet achieved full normalization of radiological and functional changes. These data provide insight into mechanisms driving development of pulmonary sequelae during and after COVID-19 and provide a rational basis for development of targeted approaches to prevent long-term complications.
| Type: | Article |
|---|---|
| Title: | A persistent neutrophil-associated immune signature characterizes post-COVID-19 pulmonary sequelae |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1126/scitranslmed.abo5795 |
| Publisher version: | https://doi.org/10.1126/scitranslmed.abo5795 |
| Language: | English |
| Additional information: | Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). |
| Keywords: | Humans, COVID-19, SARS-CoV-2, Neutrophils, Lung, Extracellular Traps |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10160233 |
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