UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans

Mauschitz, Matthias M; Verzijden, Timo; Schuster, Alexander K; Elbaz, Hisham; Pfeiffer, Norbert; Khawaja, Anthony; Luben, Robert N; ... European Eye Epidemiology (E3) Consortium; + view all (2022) Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans. British Journal of Ophthalmology -2022. 10.1136/bjo-2022-321985. (In press). Green open access

[thumbnail of Article]
Preview
Text (Article)
Khawaja_E3_AMD_medication_2022-09-24 - clean.pdf

Download (277kB) | Preview
[thumbnail of Figure 1]
Preview
Image (Figure 1)
Figure1-2022-06-07.tif - Accepted Version

Download (81kB) | Preview
[thumbnail of Figure 2]
Preview
Image (Figure 2)
Figure2-2022-06-07.tif - Accepted Version

Download (81kB) | Preview
[thumbnail of Supplementary Information 1]
Preview
Text (Supplementary Information 1)
supplemental table1.pdf - Accepted Version

Download (446kB) | Preview
[thumbnail of Supplementary Information 2]
Preview
Image (Supplementary Information 2)
Khawaja_Supplemental-figures-2022-06-07.pdf

Download (145kB) | Preview

Abstract

BACKGROUND/AIMS: To investigate the association of commonly used systemic medications with prevalent age-related macular degeneration (AMD) in the general population. METHODS: We included 38 694 adults from 14 population-based and hospital-based studies from the European Eye Epidemiology consortium. We examined associations between the use of systemic medications and any prevalent AMD as well as any late AMD using multivariable logistic regression modelling per study and pooled results using random effects meta-analysis. RESULTS: Between studies, mean age ranged from 61.5±7.1 to 82.6±3.8 years and prevalence ranged from 12.1% to 64.5% and from 0.5% to 35.5% for any and late AMD, respectively. In the meta-analysis of fully adjusted multivariable models, lipid-lowering drugs (LLD) and antidiabetic drugs were associated with lower prevalent any AMD (OR 0.85, 95% CI=0.79 to 0.91 and OR 0.78, 95% CI=0.66 to 0.91). We found no association with late AMD or with any other medication. CONCLUSION: Our study indicates a potential beneficial effect of LLD and antidiabetic drug use on prevalence of AMD across multiple European cohorts. Our findings support the importance of metabolic processes in the multifactorial aetiology of AMD.

Type: Article
Title: Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/bjo-2022-321985
Publisher version: http://dx.doi.org/10.1136/bjo-2022-321985
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10160214
Downloads since deposit
80Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item