Kandangwa, Pratik;
Torii, Ryo;
Gatehouse, Peter D;
Sherwin, Spencer J;
Weinberg, Peter D;
(2022)
Influence of right coronary artery motion, flow pulsatility and non-Newtonian rheology on wall shear stress metrics.
Frontiers in Bioengineering and Biotechnology
, 10
, Article 962687. 10.3389/fbioe.2022.962687.
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Abstract
The patchy distribution of atherosclerosis within the arterial system is consistent with a controlling influence of hemodynamic wall shear stress (WSS). Patterns of low, oscillatory and transverse WSS have been invoked to explain the distribution of disease in the aorta. Disease of coronary arteries has greater clinical importance but blood flow in these vessels may be complicated by their movement during the cardiac cycle. Previous studies have shown that time average WSS is little affected by the dynamic geometry, and that oscillatory shear is influenced more. Here we additionally investigate effects on transverse WSS. We also investigate the influence of non-Newtonian blood rheology as it can influence vortical structure, on which transverse WSS depends; Carreau-Yasuda models were used. WSS metrics were derived from numerical simulations of blood flow in a model of a moving right coronary artery which, together with a subject-specific inflow waveform, was obtained by MR imaging of a healthy human subject in a previous study. The results confirmed that time average WSS was little affected by dynamic motion and that oscillatory WSS was more affected. They additionally showed that transverse WSS and its non-dimensional analogue, the Cross Flow Index, were affected still further. This appeared to reflect time-varying vortical structures caused by the changes in curvature. The influence of non-Newtonian rheology was significant with some physiologically realistic parameter values, and hence may be important in certain subjects. Dynamic geometry and non-Newtonian rheology should be incorporated into models designed to produce maps of transverse WSS in coronary arteries.
| Type: | Article |
|---|---|
| Title: | Influence of right coronary artery motion, flow pulsatility and non-Newtonian rheology on wall shear stress metrics |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fbioe.2022.962687 |
| Publisher version: | https://doi.org/10.3389/fbioe.2022.962687 |
| Language: | English |
| Additional information: | Copyright © 2022 Kandangwa, Torii, Gatehouse, Sherwin and Weinberg. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biotechnology & Applied Microbiology, Multidisciplinary Sciences, Science & Technology - Other Topics, coronary artery disease, computational fluid dynamics, transWSS, OSI, vorticity, Dean vortex, shear thinning, TIME-DEPENDENT CURVATURE, BLOOD-FLOW, BIFURCATION, ATHEROSCLEROSIS, TUBE, COMPUTATION, PROGRESSION, VISCOSITY, TRANSPORT, PATTERNS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10160093 |
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