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Review series on helminths, immune modulation and the hygiene hypothesis: The broader implications of the hygiene hypothesis

Rook, GAW; (2009) Review series on helminths, immune modulation and the hygiene hypothesis: The broader implications of the hygiene hypothesis. Immunology , 126 (1) pp. 3-11. 10.1111/j.1365-2567.2008.03007.x. Green open access

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Abstract

Man has moved rapidly from the hunter-gatherer environment to the living conditions of the rich industrialized countries. The hygiene hypothesis suggests that the resulting changed and reduced pattern of exposure to microorganisms has led to disordered regulation of the immune system, and hence to increases in certain inflammatory disorders. The concept began with the allergic disorders, but there are now good reasons for extending it to autoimmunity, inflammatory bowel disease, neuroinflammatory disorders, atherosclerosis, depression associated with raised inflammatory cytokines, and some cancers. This review discusses these possibilities in the context of Darwinian medicine, which uses knowledge of evolution to cast light on human diseases. The Darwinian approach enables one to correctly identify some of the organisms that are important for the 'Hygiene' or 'Old Friends' hypothesis, and to point to the potential exploitation of these organisms or their components in novel types of prophylaxis with applications in several branches of medicine. © 2008 Blackwell Publishing Ltd.

Type: Article
Title: Review series on helminths, immune modulation and the hygiene hypothesis: The broader implications of the hygiene hypothesis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/j.1365-2567.2008.03007.x
Publisher version: https://doi.org/10.1111/j.1365-2567.2008.03007.x
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: evolution, hygiene hypothesis, immunoregulation, inflammation, interleukin-10
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10160044
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