Hanžel, Jurij;
Jairath, Vipul;
Ma, Christopher;
Guizzetti, Leonardo;
Zou, Guangyong;
Santillan, Cynthia S;
Taylor, Stuart A;
... Rimola, Jordi; + view all
(2022)
Responsiveness of Magnetic Resonance Enterography Indices for Evaluation of Luminal Disease Activity in Crohn's Disease.
Clinical Gastroenterology and Hepatology
, 20
(11)
pp. 2598-2606.
10.1016/j.cgh.2022.01.055.
Preview |
Text
Taylor_Responsiveness of Magnetic Resonance Enterography Indices for Evaluation of Luminal Disease Activity in Crohn's Disease.pdf Download (349kB) | Preview |
Abstract
BACKGROUND AND AIMS: Magnetic resonance enterography (MRE) is having an increasing role in Crohn's disease; however, fully validated indices are needed. We evaluated the responsiveness of 4 MRE indices in luminal Crohn's disease. METHODS: Paired MRE images (pretreatment and posttreatment at week 12/14) from 41 patients were scored by 3 blinded radiologists. Disease activity was scored for 4 MRE indices (magnetic resonance index of activity [MaRIA], simplified MaRIA, London index, and London "extended" index) and a 100-mm VAS of overall disease activity. The criterion for change was an improvement by at least one-half of an SD in the VAS after treatment. Responsiveness was evaluated using the standardized effect size (SES). Longitudinal validity was evaluated using correlations between changes in MRE index scores and disease activity measures including endoscopy and the VAS. RESULTS: The SES was 1.17 (95% CI: 0.56, 1.77) for the simplified MaRIA, 0.98 (95% CI: 0.42, 1.55) for the MaRIA, 0.95 (95% CI: 0.38, 1.51) for the London "extended" index, and 0.85 (95% CI: 0.31, 1.39) for the London index. The simplified MaRIA was significantly more responsive than the London index (ΔSES=0.32 [95% CI: 0.05, 0.58]) but not the MaRIA (ΔSES=0.18 [95% CI: -0.01, 0.38]) or London "extended" index (ΔSES=0.22 [95% CI: -0.05, 0.50]). Correlations with endoscopy (simplified MaRIA: r=0.72) were not different from correlations with the VAS (London "extended" index: r=0.70). CONCLUSIONS: Evaluated MRE indices showed moderate-to-large responsiveness and are suitable for use in clinical trials. The simplified MaRIA may be preferred due to its responsiveness and nonreliance on gadolinium administration.
| Type: | Article |
|---|---|
| Title: | Responsiveness of Magnetic Resonance Enterography Indices for Evaluation of Luminal Disease Activity in Crohn's Disease |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cgh.2022.01.055 |
| Publisher version: | https://doi.org/10.1016/j.cgh.2022.01.055 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Imaging, London index, inflammatory bowel disease, magnetic resonance index of activity |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10160026 |
Archive Staff Only
 |
View Item |
