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Extracellular matrix synthesis in vascular disease: hypertension, and atherosclerosis

Ponticos, M; Smith, BD; (2014) Extracellular matrix synthesis in vascular disease: hypertension, and atherosclerosis. Journal of Biomedical Research , 28 (1) pp. 25-39. 10.7555/JBR.27.20130064. Green open access

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Abstract

Extracellular matrix (ECM) within the vascular network provides both a structural and regulatory role. The ECM is a dynamic composite of multiple proteins that form structures connecting cells within the network. Blood vessels are distended by blood pressure and, therefore, require ECM components with elasticity yet with enough tensile strength to resist rupture. The ECM is involved in conducting mechanical signals to cells. Most importantly, ECM regulates cellular function through chemical signaling by controlling activation and bioavail- ability of the growth factors. Cells respond to ECM by remodeling their microenvironment which becomes dys- regulated in vascular diseases such hypertension, restenosis and atherosclerosis. This review examines the cellu- lar and ECM components of vessels, with specific emphasis on the regulation of collagen type I and implications in vascular disease.

Type: Article
Title: Extracellular matrix synthesis in vascular disease: hypertension, and atherosclerosis
Location: China
Open access status: An open access version is available from UCL Discovery
DOI: 10.7555/JBR.27.20130064
Publisher version: https://doi.org/10.7555/JBR.27.20130064
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: extracellular matrix, vascular disease
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10159318
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