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Genome-Edited T Cell Therapies

Ottaviano, Giorgio; Qasim, Waseem; (2022) Genome-Edited T Cell Therapies. Hematology / Oncology Clinics of North America , 36 (4) pp. 729-744. 10.1016/j.hoc.2022.03.006. Green open access

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Abstract

Chimeric antigen receptor (CAR) T-cells are widely being investigated against malignancies, and allogeneic 'universal donor' CAR-T cells offer the possibility of widened access to pre-manufactured, off-the-shelf therapies. Different genome-editing platforms have been used to address human leukocyte antigen (HLA) barriers to generate universal CAR-T cell therapy and early applications have been reported in children and adults against B cell malignancies. Recently developed Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based systems and related technologies offer the prospect of enhanced cellular immunotherapies for a wider range of hematological malignancies.

Type: Article
Title: Genome-Edited T Cell Therapies
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.hoc.2022.03.006
Publisher version: https://doi.org/10.1016/j.hoc.2022.03.006
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Base editor, CRISPR/Cas9, Chimeric antigen receptor, Cytidine deamination, Genome editing, T cell therapies
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10159110
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