Lapointe, J;
Buron, AC;
Mbuya-Bienge, C;
Dorval, M;
Pashayan, N;
Brooks, JD;
Walker, MJ;
... Nabi, H; + view all
(2022)
Polygenic risk scores and risk-stratified breast cancer screening: Familiarity and perspectives of health care professionals.
Genetics in Medicine
, 24
(11)
pp. 2380-2388.
10.1016/j.gim.2022.08.001.
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Abstract
Purpose: Health care professionals are expected to take on an active role in the implementation of risk-based cancer prevention strategies. This study aimed to explore health care professionals’ (1) self-reported familiarity with the concept of polygenic risk score (PRS), (2) perceived level of knowledge regarding risk-stratified breast cancer (BC) screening, and (3) preferences for continuing professional development. Methods: A cross-sectional survey was conducted using a bilingual—English/French—online questionnaire disseminated by health care professional associations across Canada between November 2020 and May 2021. Results: A total of 593 professionals completed more than 2 items and 453 responded to all questions. A total of 432 (94%) participants were female, 103 (22%) were physicians, and 323 (70%) were nurses. Participants reported to be unfamiliar with (20%), very unfamiliar (32%) with, or did not know (41%) the concept of PRS. Most participants reported not having enough knowledge about risk-stratified BC screening (61%) and that they would require more training (77%). Online courses and webinar conferences were the preferred continuing professional development modalities. Conclusion: The study indicates that health care professionals are currently not familiar with the concept of PRS or a risk-stratified approach for BC screening. Online information and training seem to be an essential knowledge transfer modality.
| Type: | Article |
|---|---|
| Title: | Polygenic risk scores and risk-stratified breast cancer screening: Familiarity and perspectives of health care professionals |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.gim.2022.08.001 |
| Publisher version: | https://doi.org/10.1016/j.gim.2022.08.001 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Genomic innovations, Nurses, Physicians, Precision medicine, Professional education |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Applied Health Research |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10159094 |
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