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An integrated approach to cardioprotection in lymphomas

Maraldo, MV; Levis, M; Andreis, A; Armenian, S; Bates, J; Brady, J; Ghigo, A; ... Riccardo Filippi, A; + view all (2022) An integrated approach to cardioprotection in lymphomas. The Lancet Haematology , 9 (6) e445-e454. 10.1016/S2352-3026(22)00082-5. Green open access

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Abstract

In potentially curable cancers, long-term survival depends not only on the successful treatment of the malignancy but also on the risks associated with treatment-related toxicity, especially cardiotoxicity. Malignant lymphomas affect patients at any age, with acute and late toxicity risks that could have a severe effect on morbidity, mortality, and quality of life. Although our understanding of chemotherapy-associated and radiotherapy-associated cardiovascular disease has advanced considerably, new drugs with potential cardiotoxicity have been introduced for the treatment of lymphomas. In this Review, we summarise the mechanisms of treatment-related cardiac injury, available clinical data, and protocols for optimising cardioprotection in lymphomas. We discuss ongoing research strategies to advance our knowledge of the molecular basis of drug-induced and radiation-induced toxicity. Additionally, we emphasise the potential for personalised follow-up and early detection, including the role of biomarkers and novel diagnostic tests, highlighting the role of the cardio-oncology team.

Type: Article
Title: An integrated approach to cardioprotection in lymphomas
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/S2352-3026(22)00082-5
Publisher version: https://doi.org/10.1016/S2352-3026(22)00082-5
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Antineoplastic Agents, Cardiotoxicity, Humans, Lymphoma, Neoplasms, Quality of Life
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
URI: https://discovery.ucl.ac.uk/id/eprint/10159084
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