Offenbartl-Stiegert, Daniel;
Rottensteiner, Alexia;
Dorey, Adam;
Howorka, Stefan;
(2022)
A Light-Triggered Synthetic Nanopore for Controlling Molecular Transport Across Biological Membranes.
Angewandte Chemie International Edition
, 61
(52)
, Article e202210886. 10.1002/anie.202210886.
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Abstract
Controlling biological molecular processes with light is of high interest in biological research and biomedicine, as light allows precise and selective activation in a non-invasive and non-toxic manner. A molecular process benefitting from light control is the transport of cargo across biological membranes, which is conventionally achieved by membrane-puncturing barrel-shaped nanopores. Yet, there is considerable interest to construct more complex gated pores. Here, we pioneer a synthetic light-gated nanostructure which controls transport across membranes via a controllable lid. The light-triggered nanopore is self-assembled from six pore DNA strands and a lid strand carrying light-switchable azobenzene molecules. Exposure to light opens the pore to allow small-molecule transport across membranes. Our light-triggered pore advances biomimetic chemistry and DNA nanotechnology and may be used in biotechnology, biosensing, targeted drug release, or synthetic cells.
| Type: | Article |
|---|---|
| Title: | A Light-Triggered Synthetic Nanopore for Controlling Molecular Transport Across Biological Membranes |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/anie.202210886 |
| Publisher version: | https://doi.org/10.1002/anie.202210886 |
| Language: | English |
| Additional information: | Copyright © 2022 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10158974 |
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