Howarth, C;
Banerjee, J;
Eaton, Simon;
Aladangady, N;
(2022)
Biomarkers of gut injury in neonates – where are we in predicting Necrotising Enterocolitis?
Frontiers in Pediatrics
, 10
, Article 1048322. 10.3389/fped.2022.1048322.
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Abstract
Despite advances in neonatal care Necrotising Enterocolitis (NEC) continues to have a significant mortality and morbidity rate, and with increasing survival of those more immature infants the population at risk of NEC is increasing. Ischaemia, reperfusion, and inflammation underpin diseases affecting intestinal blood flow causing gut injury including Necrotising Enterocolitis. There is increasing interest in tissue biomarkers of gut injury in neonates, particularly those representing changes in intestinal wall barrier and permeability, to determine whether these could be useful biomarkers of gut injury. This article reviews current and newly proposed markers of gut injury, the available literature evidence, recent advances and considers how effective they are in clinical practice. We discuss each biomarker in terms of its effectiveness in predicting NEC onset and diagnosis or predicting NEC severity and then those that will aid in surveillance and identifying those infants are greatest risk of developing NEC.
| Type: | Article |
|---|---|
| Title: | Biomarkers of gut injury in neonates – where are we in predicting Necrotising Enterocolitis? |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fped.2022.1048322 |
| Publisher version: | https://doi.org/10.3389/fped.2022.1048322 |
| Language: | English |
| Additional information: | © 2022 Howarth, Banerjee, Eaton and Aladangady. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | NEC, biomarker, gut oxygenation, tissue injury, ischaemia |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10158918 |
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