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Long-term effect of SARS-CoV-2 infection on cardiovascular outcomes and all-cause mortality

Aleksova, A; Fluca, AL; Gagno, G; Pierri, A; Padoan, L; Derin, A; Moretti, R; ... Janjusevic, M; + view all (2022) Long-term effect of SARS-CoV-2 infection on cardiovascular outcomes and all-cause mortality. Life Sciences , 310 , Article 121018. 10.1016/j.lfs.2022.121018. Green open access

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Abstract

Since the very beginning of the coronavirus disease 2019 (COVID-19) pandemic in early 2020, it was evident that patients with cardiovascular disease (CVD) were at an increased risk of developing severe illness, and complications spanning cerebrovascular disorders, dysrhythmias, acute coronary syndrome, ischemic and non-ischemic heart disease, pericarditis, myocarditis, heart failure, thromboembolic disease, stroke, and death. Underlying these was excessive systemic inflammation and coagulopathy due to SARS-COV-2 infection, the effects of which also continued long-term as evidenced by post-COVID-19 cardiovascular complications. The acute and chronic cardiovascular effects of COVID-19 occurred even among those who were not hospitalized and had no previous CVD or those with mild symptoms. This comprehensive review summarizes the current understanding of molecular mechanisms triggered by the SARS-CoV-2 virus on various cells that express the angiotensin-converting enzyme 2, leading to endothelial dysfunction, inflammation, myocarditis, impaired coagulation, myocardial infarction, arrhythmia and a multisystem inflammatory syndrome in children or Kawasaki-like disease.

Type: Article
Title: Long-term effect of SARS-CoV-2 infection on cardiovascular outcomes and all-cause mortality
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.lfs.2022.121018
Publisher version: https://doi.org/10.1016/j.lfs.2022.121018
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: COVID-19, Endothelial dysfunction, Inflammation, Myocardial injury, Oxidative stress, Thrombosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10158910
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