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Equivocal, explicit and emergent actions of PKC isoforms in cancer

Parker, Peter J; Brown, Sophie J; Calleja, Veronique; Chakravarty, Probir; Cobbaut, Mathias; Linch, Mark; Marshall, Jacqueline JT; ... Watson, Lisa; + view all (2021) Equivocal, explicit and emergent actions of PKC isoforms in cancer. NATURE REVIEWS CANCER , 21 (1) pp. 51-63. 10.1038/s41568-020-00310-4. Green open access

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Abstract

The maturing mutational landscape of cancer genomes, the development and application of clinical interventions and evolving insights into tumour-associated functions reveal unexpected features of the protein kinase C (PKC) family of serine/threonine protein kinases. These advances include recent work showing gain or loss-of-function mutations relating to driver or bystander roles, how conformational constraints and plasticity impact this class of proteins and how emergent cancer-associated properties may offer opportunities for intervention. The profound impact of the tumour microenvironment, reflected in the efficacy of immune checkpoint interventions, further prompts to incorporate PKC family actions and interventions in this ecosystem, informed by insights into the control of stromal and immune cell functions. Drugging PKC isoforms has offered much promise, but when and how is not obvious.

Type: Article
Title: Equivocal, explicit and emergent actions of PKC isoforms in cancer
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41568-020-00310-4
Publisher version: https://doi.org/10.1038/s41568-020-00310-4
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10158758
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