Díaz-Torres, E;
Rodríguez-Pombo, L;
Ong, JJ;
Basit, AW;
Santoveña-Estévez, A;
Fariña, JB;
Alvarez-Lorenzo, C;
(2022)
Integrating pressure sensor control into semi-solid extrusion 3D printing to optimize medicine manufacturing.
International Journal of Pharmaceutics: X
, 4
, Article 100133. 10.1016/j.ijpx.2022.100133.
Preview |
Text
1-s2.0-S2590156722000226-main.pdf - Published Version Download (11MB) | Preview |
Abstract
Semi-solid extrusion (SSE) is a three-dimensional printing (3DP) process that involves the extrusion of a gel or paste-like material via a syringe-based printhead to create the desired object. In pharmaceuticals, SSE 3DP has already been used to manufacture formulations for human clinical studies. To further support its clinical adoption, the use of a pressure sensor may provide information on the printability of the feedstock material in situ and under the exact printing conditions for quality control purposes. This study aimed to integrate a pressure sensor in an SSE pharmaceutical 3D printer for both material characterization and as a process analytical technology (PAT) to monitor the printing process. In this study, three materials of different consistency were tested (soft vaseline, gel-like mass and paste-like mass) under 12 different conditions, by changing flow rate, temperature, or nozzle diameter. The use of a pressure sensor allowed, for the first time, the characterization of rheological properties of the inks, which exhibited temperature-dependent, plastic and viscoelastic behaviours. Controlling critical material attributes and 3D printing process parameters may allow a quality by design (QbD) approach to facilitate a high-fidelity 3D printing process critical for the future of personalized medicine.
| Type: | Article |
|---|---|
| Title: | Integrating pressure sensor control into semi-solid extrusion 3D printing to optimize medicine manufacturing |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ijpx.2022.100133 |
| Publisher version: | https://doi.org/10.1016/j.ijpx.2022.100133 |
| Language: | English |
| Additional information: | Copyright © 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/). |
| Keywords: | Ink characterization, Rheology, Printing formulations and drug products, Process analytical technology (PAT), Paediatric formulations, Direct ink writing of medicines, 3D printed pharmaceuticals and drug delivery systems |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10158680 |
Archive Staff Only
 |
View Item |
