Elangovan, Ramyia;
Baruteau, Julien;
(2022)
Inherited and acquired vitamin B12 deficiencies: Which administration route to choose for supplementation?
Frontiers in Pharmacology
, 13
, Article 972468. 10.3389/fphar.2022.972468.
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Abstract
Vitamin B12 or cobalamin deficiency is a commonly encountered clinical scenario and most clinicians will have familiarity prescribing Vitamin B12 to treat their patients. Despite the high prevalence of this condition, there is widespread heterogeneity regarding routes, schedules and dosages of vitamin B12 administration. In this review, we summarise the complex metabolic pathway of Vitamin B12, the inherited and acquired causes of Vitamin B12 deficiency and subsequently highlight the disparate international practice of prescribing Vitamin B12 replacement therapy. We describe the evidence base underpinning the novel sublingual, intranasal and subcutaneous modes of B12 replacement in comparison to intramuscular and oral routes, with their respective benefits for patient compliance and cost-saving.
| Type: | Article |
|---|---|
| Title: | Inherited and acquired vitamin B12 deficiencies: Which administration route to choose for supplementation? |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fphar.2022.972468 |
| Publisher version: | https://doi.org/10.3389/fphar.2022.972468 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, cobalamin, hydroxocobalamin, cyanocobalamin, vitamin B12, metabolic, PERNICIOUS-ANEMIA, INBORN ERROR, REMETHYLATION DISORDERS, COBALAMIN METABOLISM, ORAL TREATMENT, MUTATIONS, DIAGNOSIS, THERAPY, HOMOCYSTEINE, GUIDELINES |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10158402 |
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