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Matrix-enabled mechanobiological modulation of osteoimmunology

Lee, JH; Park, JH; Lee, JH; Lee, HH; Knowles, JC; Kim, HW; (2022) Matrix-enabled mechanobiological modulation of osteoimmunology. Matter , 5 (10) pp. 3194-3224. 10.1016/j.matt.2022.07.002. Green open access

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Abstract

Modulation of osteoimmunology is central to recovering the functions of defective and diseased bone. Here, we highlight the roles of material-enabled matrix in regulating osteoimmunological phenomena such as inflammation, bone hemostasis, and regeneration. We provide an overview of the concept of osteoimmunology and matrix-induced mechanobiology, detail the effort to exploit materials with tunable parameters (ligands, stiffness, viscoelasticity, nano/microtopography, and three-dimensionality) to instruct these events, and discuss the mechanotransduction process and mechanisms underlying the matrix-related interactions between immune/inflammatory cells and bone-forming cells. This will help us to understand matrix-related mechanobiological modulation of osteoimmunology and develop materials with tunable matrix properties for bone healing and regeneration.

Type: Article
Title: Matrix-enabled mechanobiological modulation of osteoimmunology
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.matt.2022.07.002
Publisher version: https://doi.org/10.1016/j.matt.2022.07.002
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Matrix properties, mechanobiology, osteoimmunology, cell-matrix interactions, bone
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10158265
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