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Nucleosome disruption by 5-bromodeoxyuridine leads to senescence

Guerrero, Ana; (2023) Nucleosome disruption by 5-bromodeoxyuridine leads to senescence. The FEBS Journal , 290 (3) pp. 684-687. 10.1111/febs.16630. Green open access

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Abstract

5-Bromodeoxyuridine (BrdU) exposure leads to senescence, but the mechanistic details remain elusive. In this issue, En A et al. unveil a role of the HBR domain in histone H2B as a potential mediator of the effects of BrdU both in yeast and in human cells. Comment on: https://doi.org/10.1111/febs.16584.

Type: Article
Title: Nucleosome disruption by 5-bromodeoxyuridine leads to senescence
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/febs.16630
Publisher version: https://doi.org/10.1111/febs.16630
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: BrdU, SASP, cellular senescence, epigenetics, nucleosomes
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > UK Dementia Research Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/10158249
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