Peters, Andrew J; Marica, Andrada-Maria; Fabre, Julie MJ; Harris, Kenneth D; Carandini, Matteo; (2022) Visuomotor learning promotes visually evoked activity in the medial prefrontal cortex. Cell Reports , 41 (3) , Article 111487. 10.1016/j.celrep.2022.111487.

Preview

Text 1-s2.0-S2211124722013377-main.pdf - Published Version Download (2MB) | Preview

Abstract

The medial prefrontal cortex (mPFC) is necessary for executing many learned associations between stimuli and movement. It is unclear, however, how activity in the mPFC evolves across learning, and how this activity correlates with sensory stimuli and the learned movements they evoke. To address these questions, we record cortical activity with widefield calcium imaging while mice learned to associate a visual stimulus with a forelimb movement. After learning, the mPFC shows stimulus-evoked activity both during task performance and during passive viewing, when the stimulus evokes no action. This stimulus-evoked activity closely tracks behavioral performance across training, with both exhibiting a marked increase between days when mice first learn the task, followed by a steady increase with further training. Electrophysiological recordings localized this activity to the secondary motor and anterior cingulate cortex. We conclude that learning a visuomotor task promotes a route for visual information to reach the prefrontal cortex.

Download activity - last month

Export as JSONCSVXML

Download activity - last 12 months

Export as XMLCSVJSON

Downloads by country - last 12 months

Export as CSVXMLJSON

Archive Staff Only

View Item