UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Visuomotor learning promotes visually evoked activity in the medial prefrontal cortex

Peters, Andrew J; Marica, Andrada-Maria; Fabre, Julie MJ; Harris, Kenneth D; Carandini, Matteo; (2022) Visuomotor learning promotes visually evoked activity in the medial prefrontal cortex. Cell Reports , 41 (3) , Article 111487. 10.1016/j.celrep.2022.111487. Green open access

[thumbnail of 1-s2.0-S2211124722013377-main.pdf]
Preview
Text
1-s2.0-S2211124722013377-main.pdf - Published Version

Download (2MB) | Preview

Abstract

The medial prefrontal cortex (mPFC) is necessary for executing many learned associations between stimuli and movement. It is unclear, however, how activity in the mPFC evolves across learning, and how this activity correlates with sensory stimuli and the learned movements they evoke. To address these questions, we record cortical activity with widefield calcium imaging while mice learned to associate a visual stimulus with a forelimb movement. After learning, the mPFC shows stimulus-evoked activity both during task performance and during passive viewing, when the stimulus evokes no action. This stimulus-evoked activity closely tracks behavioral performance across training, with both exhibiting a marked increase between days when mice first learn the task, followed by a steady increase with further training. Electrophysiological recordings localized this activity to the secondary motor and anterior cingulate cortex. We conclude that learning a visuomotor task promotes a route for visual information to reach the prefrontal cortex.

Type: Article
Title: Visuomotor learning promotes visually evoked activity in the medial prefrontal cortex
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.celrep.2022.111487
Publisher version: https://doi.org/10.1016/j.celrep.2022.111487
Language: English
Additional information: Copyright © 2022 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: cortex, sensorimotor, learning, visual, mPFC
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10158153
Downloads since deposit
34Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item