Chadwick, Angus;
Khan, Adil G;
Poort, Jasper;
Blot, Antonin;
Hofer, Sonja B;
Mrsic-Flogel, Thomas D;
Sahani, Maneesh;
(2022)
Learning shapes cortical dynamics to enhance integration of relevant sensory input.
Neuron
10.1016/j.neuron.2022.10.001.
(In press).
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Abstract
Adaptive sensory behavior is thought to depend on processing in recurrent cortical circuits, but how dynamics in these circuits shapes the integration and transmission of sensory information is not well understood. Here, we study neural coding in recurrently connected networks of neurons driven by sensory input. We show analytically how information available in the network output varies with the alignment between feedforward input and the integrating modes of the circuit dynamics. In light of this theory, we analyzed neural population activity in the visual cortex of mice that learned to discriminate visual features. We found that over learning, slow patterns of network dynamics realigned to better integrate input relevant to the discrimination task. This realignment of network dynamics could be explained by changes in excitatory-inhibitory connectivity among neurons tuned to relevant features. These results suggest that learning tunes the temporal dynamics of cortical circuits to optimally integrate relevant sensory input.
| Type: | Article |
|---|---|
| Title: | Learning shapes cortical dynamics to enhance integration of relevant sensory input |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neuron.2022.10.001 |
| Publisher version: | https://doi.org/10.1016/j.neuron.2022.10.001 |
| Language: | English |
| Additional information: | Copyright © 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | neural coding, network dynamics, cortical circuits, learning, decision making, visual cortex, noise correlations, computational model, dynamical systems, sensory processing |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Gatsby Computational Neurosci Unit UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10158046 |
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