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Development of a Biosensor for fast point-of-care Blood Analysis of Troponin

Bayford, R; Damaso, R; Jiang, D; Rahal, M; Demosthenous, A; (2022) Development of a Biosensor for fast point-of-care Blood Analysis of Troponin. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference , 2022 pp. 910-913. 10.1109/EMBC48229.2022.9871851. Green open access

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Abstract

We present the development of novel tetrapolar EIS biosensor for the detect of troponin. Troponin has considerable diagnostic power and provide invaluable prognostic information for risk stratification. of acute coronary syndromes. Clinical Relevance- A feasibility study was undertaken to assess the diagnostic performance of serial cardiac troponin measurements which is excellent as these structural proteins are unique to the heart and thus sensitive and specific of damage to the myocardium. clinical molecular diagnostics and home healthcare. Troponin's biosensors would provide point-of-care and rapid decision making for the early detection of CS. Clinically relevant window of cTnI testing, concentrations from 10pM to 0.1μM were achieved.

Type: Article
Title: Development of a Biosensor for fast point-of-care Blood Analysis of Troponin
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/EMBC48229.2022.9871851
Publisher version: https://doi.org/10.1109/EMBC48229.2022.9871851
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Biomarkers, Biosensing Techniques, Hematologic Tests, Point-of-Care Systems, Troponin I
UCL classification: UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10157944
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