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Development of a novel scale-down method to study pH and dissolved oxygen heterogeneities in mammalian cell cultures

Zakrzewski, Roman; (2022) Development of a novel scale-down method to study pH and dissolved oxygen heterogeneities in mammalian cell cultures. Doctoral thesis (Eng.D), UCL (University College London). Green open access

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Abstract

In recent years, there has been a growing interest in studying the effects of spatial heterogeneities that are present in large-scale cell culture bioreactors. When scaling up from bench-top to production bioreactors mixing times often increase, which make heterogeneities within large-scale vessels more likely.

Type: Thesis (Doctoral)
Qualification: Eng.D
Title: Development of a novel scale-down method to study pH and dissolved oxygen heterogeneities in mammalian cell cultures
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Copyright © The Author 2022. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author's request.
UCL classification: UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10157903
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