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Exploiting the potential of lung stem cells to develop pro-regenerative therapies

Hynds, Robert E; (2022) Exploiting the potential of lung stem cells to develop pro-regenerative therapies. Biology Open , 11 (10) , Article bio059423. 10.1242/bio.059423. Green open access

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Abstract

Acute and chronic lung diseases are a leading cause of morbidity and mortality globally. Unfortunately, these diseases are increasing in frequency and we have limited treatment options for severe lung diseases. New therapies are needed that not only treat symptoms or slow disease progression, but also enable the regeneration of functional lung tissue. Both airways and alveoli contain populations of epithelial stem cells with the potential to self-renew and produce differentiated progeny. Understanding the mechanisms that determine the behaviour of these cells, and their interactions with their niches, will allow future generations of respiratory therapies that protect the lungs from disease onset, promote regeneration from endogenous stem cells or enable regeneration through the delivery of exogenous cells. This review summarises progress towards each of these goals, highlighting the challenges and opportunities of developing pro-regenerative (bio)pharmaceutical, gene and cell therapies for respiratory diseases.

Type: Article
Title: Exploiting the potential of lung stem cells to develop pro-regenerative therapies
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1242/bio.059423
Publisher version: https://doi.org/10.1242/bio.059423
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed
Keywords: Cell transplantation, Epithelial stem cells, Lung regeneration, Regenerative medicine, Respiratory biology, Humans, Lung, Lung Diseases, Pharmaceutical Preparations, Stem Cell Transplantation
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10157654
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