UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Stroke disconnectome decodes reading networks

Forkel, Stephanie J; Labache, Loïc; Nachev, Parashkev; Thiebaut de Schotten, Michel; Hesling, Isabelle; (2022) Stroke disconnectome decodes reading networks. Brain Structure and Function 10.1007/s00429-022-02575-x. (In press). Green open access

[thumbnail of Nachev_Stroke disconnectome decodes reading networks_AOP.pdf]
Preview
PDF
Nachev_Stroke disconnectome decodes reading networks_AOP.pdf - Published Version

Download (945kB) | Preview

Abstract

Cognitive functional neuroimaging has been around for over 30 years and has shed light on the brain areas relevant for reading. However, new methodological developments enable mapping the interaction between functional imaging and the underlying white matter networks. In this study, we used such a novel method, called the disconnectome, to decode the reading circuitry in the brain. We used the resulting disconnection patterns to predict a typical lesion that would lead to reading deficits after brain damage. Our results suggest that white matter connections critical for reading include fronto-parietal U-shaped fibres and the vertical occipital fasciculus (VOF). The lesion most predictive of a reading deficit would impinge on the left temporal, occipital, and inferior parietal gyri. This novel framework can systematically be applied to bridge the gap between the neuropathology of language and cognitive neuroscience.

Type: Article
Title: Stroke disconnectome decodes reading networks
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00429-022-02575-x
Publisher version: https://doi.org/10.1007/s00429-022-02575-x
Language: English
Additional information: © The Author(s) 2022.This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Disconnection, Exner, Language, Reading, Stroke, VOF, fMRI
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/10157522
Downloads since deposit
35Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item