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From novel discovery tools and biomarkers to precision medicine—basic cardiovascular science highlights of 2021/22

Evans, Paul C; Davidson, Sean M; Wojta, Johann; Baeck, Magnus; Bollini, Sveva; Brittan, Mairi; Catapano, Alberico L; ... Weber, Christian; + view all (2022) From novel discovery tools and biomarkers to precision medicine—basic cardiovascular science highlights of 2021/22. Cardiovascular Research , 118 (13) pp. 2754-2567. 10.1093/cvr/cvac114. Green open access

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Abstract

Here we review the highlights of cardiovascular basic science in published in 2021 and early 2022 on behalf of the European Society of Cardiology Council for Basic Cardiovascular Science. We begin with non-coding RNAs which have emerged as central regulators cardiovascular biology, and then discuss how technological developments in single-cell 'omics are providing new insights in cardiovascular development, inflammation and disease. We also review recent discoveries on the biology of extracellular vesicles in driving either protective or pathogenic responses. The Nobel Prize in Physiology or Medicine 2021 recognised the importance of the molecular basis of mechanosensing and here we review breakthroughs in cardiovascular sensing of mechanical force. We also summarise discoveries in the field of atherosclerosis including the role of clonal haematopoiesis of indeterminate potential, and new mechanisms of cross-talk between hyperglycemia, lipid mediators and inflammation. The past 12 months also witnessed major advances in the field of cardiac arrhythmia including new mechanisms of fibrillation. We also focus on inducible pluripotent stem cell (iPSC) technology which has demonstrated disease causality for several genetic polymorphisms in long QT syndrome and aortic valve disease, paving the way for personalized medicine approaches. Finally, the cardiovascular community has continued to better understand COVID-19 with significant advancement in our knowledge of cardiovascular tropism, molecular markers, the mechanism of vaccine-induced thrombotic complications and new anti-viral therapies that protect the cardiovascular system.

Type: Article
Title: From novel discovery tools and biomarkers to precision medicine—basic cardiovascular science highlights of 2021/22
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/cvr/cvac114
Publisher version: https://doi.org/10.1093/cvr/cvac114
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cardiology, Vascular, Biomarkers, Precision medicine
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10157473
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