Sanchez Clemente, Nuria;
Penner, Justin;
Breuer, Judith;
Ip, Winnie;
Booth, Claire;
(2022)
Case Report: A Severe Paediatric Presentation of COVID-19 in APDS2 Immunodeficiency.
Frontiers in Immunology
, 13
, Article 881259. 10.3389/fimmu.2022.881259.
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Abstract
Critical respiratory manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are rare in children, and little is known about how immunocompromised children respond to the infection. We report a case of a 4-year-old boy with activated PI3K delta syndrome type 2 (APDS2) with a protracted and severe COVID-19 course with both inflammatory and acute respiratory features. He was treated with remdesivir, nitazoxanide, high-dose corticosteroids, and tocilizumab and made a full recovery. We propose that remdesivir may be used in combination with nitazoxanide to improve viral clearance and reduce the chance of resistance in treating acute SARS-CoV-2 infection.
| Type: | Article |
|---|---|
| Title: | Case Report: A Severe Paediatric Presentation of COVID-19 in APDS2 Immunodeficiency |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fimmu.2022.881259 |
| Publisher version: | https://doi.org/10.3389/fimmu.2022.881259 |
| Language: | English |
| Additional information: | © 2022 Sanchez Clemente, Penner, Breuer, Ip and Booth. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Immunology, primary immunodeficiency, APDS2, SARS-CoV-2, COVID-19, case report |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10157397 |
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