Alsugeir, Dana;
Wei, Li;
Adesuyan, Matthew;
Cook, Sarah;
Panay, Nicholas;
Brauer, Ruth;
(2022)
Hormonal replacement therapy prescribing in menopausal women in the UK: A descriptive study.
BJGP Open
10.3399/bjgpo.2022.0126.
(In press).
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Abstract
Background Recent studies on the prescribing of hormonal replacement therapy (HRT) medicines to treat symptoms of menopause are lacking. Aim To describe the prescribing of HRT in a cohort of UK menopausal women. Design & setting Population-based drug utilization study using IQVIA Medical Research Database. Method Primary care data of women with recorded menopause and/or 50 years and older between January 2010 and November 2021 were extracted from the database. The incidence rate (IR) of women who received their first prescription for HRT was calculated annually using person-years at risk (PYAR) as the denominator. IRs of HRT were estimated by type and route of administration. Relative changes in annual IR were expressed as percentages and the average percentage change was assessed using linear regression. Annual prescribing prevalence per 100 women was calculated using mid-year menopausal population estimates. Results The IR of prescribing of HRT increased from 5.01 in 2010–18.16 per 1000 PYAR in 2021, a relative increase of 13.64% (95% CI 6.97–20.30) per year. IR of fixed combinations of HRT increased from 3.33 to 12.23 per 1000 PYAR in 2010 and 2021, respectively. Transdermal formulations of HRT increased from 1.48 to 14.55 per 1000 PYAR in 2010 and 2021, respectively. The overall proportion of women in receipt of a prescription for HRT changed from 7.89% in 2010 to 6.8% in 2020. Conclusion Our study shows steady increase in the number of women receiving their first prescription for HRT during the study period which suggests regained acceptance of HRT medicines.
| Type: | Article |
|---|---|
| Title: | Hormonal replacement therapy prescribing in menopausal women in the UK: A descriptive study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3399/bjgpo.2022.0126 |
| Publisher version: | http://doi.org/10.3399/bjgpo.2022.0126 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Menopause, Hormonal replacement therapy, HRT, perimenopausal |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10157338 |
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