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Evaluation of A Novel Organ Perfusion Research Platform

Magbagbeola, M; Doyle, K; Rai, ZL; Lindenroth, L; Dwyer, G; Stilli, A; Davidson, BR; (2022) Evaluation of A Novel Organ Perfusion Research Platform. In: 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). (pp. pp. 2565-2568). IEEE: Glasgow, Scotland, United Kingdom. Green open access

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Abstract

This paper presents a novel, low cost, organ perfusion machine designed for use in research. The modular and versatile nature of the system allows for additional sensing equipment to be added or adapted for specific use. Here we introduce the system and present its preliminary evaluation by assessing its ability to maintain a predetermined input pressure. A proportional-integral-derivative (PID) controller was implemented and tested on a porcine liver to maintain input pressure to the hepatic artery and compared to bench tests. The results confirmed the effectiveness of the controller for maintaining input through the hepatic artery (HA) in a timely manner. Clinical Relevance-Machine Perfusion (MP) is proving to be an invaluable adjunct in clinical practice. With its ongoing success in the transplant arena, we propose MP for use in research. A cost-effective, versatile system that can be modified for specific research use to test new pharmacological therapies, imaging techniques or develop simulation training would be beneficial.

Type: Proceedings paper
Title: Evaluation of A Novel Organ Perfusion Research Platform
Event: 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Location: United States
Dates: 11 Jul 2022 - 15 Jul 2022
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/EMBC48229.2022.9871028
Publisher version: https://doi.org/10.1109/EMBC48229.2022.9871028
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Animals, Liver, Perfusion, Swine, Training, Costs, Medical treatment, Liver, Imaging, Biological systems, Sensors
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10157325
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