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Regenerative medicine: prenatal approaches

de Coppi, Paolo; Loukogeorgakis, Stavros; Götherström, Cecilia; David, Anna L; Almeida-Porada, Graça; Chan, Jerry KY; Deprest, Jan; ... Tam, Paul Kwong Hang; + view all (2022) Regenerative medicine: prenatal approaches. The Lancet Child and Adolescent Health , 6 (9) pp. 643-653. 10.1016/S2352-4642(22)00192-4. Green open access

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Abstract

This two-paper Series focuses on recent advances and applications of regenerative medicine that could benefit paediatric patients. Innovations in genomic, stem-cell, and tissue-based technologies have created progress in disease modelling and new therapies for congenital and incurable paediatric diseases. Prenatal approaches present unique opportunities associated with substantial biotechnical, medical, and ethical obstacles. Maternal plasma fetal DNA analysis is increasingly adopted as a noninvasive prenatal screening or diagnostic test for chromosomal and monogenic disorders. The molecular basis for cell-free DNA detection stimulated the development of circulating tumour DNA testing for adult cancers. In-utero stem-cell, gene, gene-modified cell (and to a lesser extent, tissue-based) therapies have shown early clinical promise in a wide range of paediatric disorders. Fetal cells for postnatal treatment and artificial placenta for ex-utero fetal therapies are new frontiers in this exciting field.

Type: Article
Title: Regenerative medicine: prenatal approaches
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/S2352-4642(22)00192-4
Publisher version: https://doi.org/10.1016/S2352-4642(22)00192-4
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Child, DNA, Female, Fetus, Humans, Pregnancy, Prenatal Care, Prenatal Diagnosis, Regenerative Medicine
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
URI: https://discovery.ucl.ac.uk/id/eprint/10156952
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