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The burden of asthma, hay fever and eczema in children in 25 countries: GAN Phase I study

García-Marcos, Luis; Asher, M Innes; Pearce, Neil; Ellwood, Eamon; Bissell, Karen; Chiang, Chen-Yuan; El Sony, Asma; ... Global Asthma Network Phase I Study Group, .; + view all (2022) The burden of asthma, hay fever and eczema in children in 25 countries: GAN Phase I study. European Respiratory Journal , 60 (3) , Article 2102866. 10.1183/13993003.02866-2021. Green open access

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Abstract

AIMS: There have been no worldwide standardised surveys of prevalence and severity of asthma, rhinoconjunctivitis and eczema in school children for 15 years. The present study aims to provide this information. METHODS: Following the exact International Study of Asthma and Allergies in Childhood (ISAAC) methodology (cross-sectional questionnaire-based survey), Global Asthma Network (GAN) Phase I was carried out between 2015 and 2020 in many centres worldwide. RESULTS: The study included 157 784 adolescents (13-14 years of age) in 63 centres in 25 countries and 101 777 children (6-7 years of age) in 44 centres in 16 countries. The current prevalence of symptoms, respectively, was 11.0% and 9.1% for asthma, 13.3% and 7.7% for rhinoconjunctivitis and 6.4% and 5.9% for eczema. The prevalence of asthma ever was 10.5% and 7.6%, hay fever ever was 15.2% and 11.1% and eczema ever was 10.6% and 13.4%, respectively. Centres in low or lower middle gross national income countries (LICs or LMICs) had significantly lower prevalence of the three disease symptoms and diagnoses (except for hay fever). In children, the prevalence of asthma and rhinoconjunctivitis symptoms was higher in boys, while the reverse occurred among adolescents. For eczema, while the prevalence among female adolescents was double that of males, there was no sex difference among children. Centre accounted for non-negligible variability in all disease symptoms (10-20%). CONCLUSION: The burdens of asthma, rhinoconjunctivitis and eczema vary widely among the limited number of countries studied. Although symptom prevalence is lower in LICs and LMICs, it represents a considerable burden everywhere studied.

Type: Article
Title: The burden of asthma, hay fever and eczema in children in 25 countries: GAN Phase I study
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1183/13993003.02866-2021
Publisher version: https://doi.org/10.1183/13993003.02866-2021
Language: English
Additional information: © The authors 2022. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0 (https://creativecommons.org/licenses/by-nc/4.0/).
Keywords: Adolescent, Asthma, Child, Conjunctivitis, Cross-Sectional Studies, Eczema, Female, Humans, Hypersensitivity, Male, Prevalence, Rhinitis, Allergic, Seasonal, Surveys and Questionnaires
UCL classification: UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education
UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education > IOE - Social Research Institute
UCL > Provost and Vice Provost Offices > School of Education
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10156686
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