Lehtinen, Matti;
Pimenoff, Ville N;
Nedjai, Belinda;
Louvanto, Karolina;
Verhoef, Lisanne;
Heideman, Daniëlle AM;
El-Zein, Mariam;
... Dillner, Joakim; + view all
(2023)
Assessing the risk of cervical neoplasia in the post-HPV vaccination era.
International Journal of Cancer
, 152
(6)
pp. 1060-1068.
10.1002/ijc.34286.
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Abstract
This review is based on the recent EUROGIN scientific session: "Assessing risk of cervical cancer in the post-vaccinaton era" that addressed the demands of cervical intraepithelial neoplasia (CIN)/ squamous intraepithelial lesion (SIL) triage now that the prevalence of vaccine-targeted oncogenic high-risk (hr) human papillomaviruses (HPVs) is decreasing. Change in the prevalence distribution of oncogenic HPV types that follows national HPV vaccination programs is setting the stage for loss of positive predictive value of conventional but possibly also new triage modalities. Understanding contribution of the latter, most notably hypermethylation of cellular and viral genes in a new setting where most oncogenic HPV types are no longer present, requires studies on their performance in vaccinated women with CIN/SIL that are associated with non-vaccine HPV types. Lessons learned from this research may highlight the potential of cervical cells for risk prediction of all women's cancers. This article is protected by copyright. All rights reserved.
| Type: | Article |
|---|---|
| Title: | Assessing the risk of cervical neoplasia in the post-HPV vaccination era |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/ijc.34286 |
| Publisher version: | https://doi.org/10.1002/ijc.34286 |
| Language: | English |
| Additional information: | Copyright © 2022 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| Keywords: | cervical cancer, epigenetics, gynaecological cancers, human papillomavirus, methylation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10156430 |
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