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Cerebral perfusion in untreated, controlled, and uncontrolled hypertension

Christie, Isabel N; Windsor, Rowan; Mutsaerts, Henk JMM; Tillin, Therese; Sudre, Carole H; Hughes, Alun D; Golay, Xavier; ... Hosford, Patrick S; + view all (2022) Cerebral perfusion in untreated, controlled, and uncontrolled hypertension. Journal of Cerebral Blood Flow and Metabolism 10.1177/0271678x221124644. (In press). Green open access

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Abstract

This study evaluated the association between systemic arterial blood pressure and cerebral perfusion in 740 participants of the UK's largest tri-ethnic study with measurements of cerebral blood flow (CBF) performed using arterial spin labelling MRI. A significant negative correlation between blood pressure, age and CBF was observed across the patient cohort. The lowest CBF values were recorded in the group of patients with hypertension that were prescribed with anti-hypertensive drugs, but uncontrolled on medication. These findings confirm that hypertension is associated with reduced cerebral perfusion and highlight the importance of blood pressure control for the benefit of maintaining brain blood flow.

Type: Article
Title: Cerebral perfusion in untreated, controlled, and uncontrolled hypertension
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/0271678x221124644
Publisher version: https://doi.org/10.1177/0271678X221124644
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10156183
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