Scleroderma autoantibodies in guiding monitoring and treatment decisions

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Scleroderma autoantibodies in guiding monitoring and treatment decisions

Shah, Shivani; Denton, Christopher P; (2022) Scleroderma autoantibodies in guiding monitoring and treatment decisions. Current Opinion in Rheumatology , 34 (6) pp. 302-310. 10.1097/BOR.0000000000000904. Green open access

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Abstract

PURPOSE OF REVIEW: One of the key clinical challenges of systemic sclerosis (SSc) is diversity in clinical presentation, organ involvement and disease progression. Antinuclear autoantibodies (ANA) are central to the diagnosis of SSc. ANA specificities associated with distinct clinical patterns of organ and skin involvement. Understanding of the molecular differences and pathogenesis of scleroderma has helped further inform clinical acumen. Here, we provide an update on ANA on clinical profiling, management and future direction of SSc. RECENT FINDINGS: There has been further development in delineating clinical patterns in ANA, genetic susceptibility and antigen triggers predisposing to ANA subtypes. Sub-group analysis of recent clinical trials shows differing treatment responses to novel therapeutics. SUMMARY: ANA subtyping is likely to be firmly embedded into future classification systems. Beyond informing current management and monitoring of scleroderma patients, ANA subsets have implication on future research and clinical trial design.

Type:	Article
Title:	Scleroderma autoantibodies in guiding monitoring and treatment decisions
Location:	United States
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1097/BOR.0000000000000904
Publisher version:	https://doi.org/10.1097/BOR.0000000000000904
Language:	English
Additional information:	This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification:	UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
URI:	https://discovery.ucl.ac.uk/id/eprint/10155893