Hird, Emily J;
Beierholm, Ulrik;
De Boer, Lieke;
Axelsson, Jan;
Backman, Lars;
Guitart-Masip, Marc;
(2022)
Dopamine and reward-related vigor in younger and older adults.
Neurobiology of Aging
, 118
pp. 34-43.
10.1016/j.neurobiolaging.2022.06.003.
(In press).
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Abstract
Vigor reflects how motivated people are to respond to stimuli. We previously showed that, on average, humans are more vigorous when a higher rate of reward is available, and that this relationship is modulated by the dopamine precursor levodopa. Dopamine signaling and probabilistic reward learning deteriorate across the adult life span, and thus, the relationship between vigor and reward may also change in aging. We tested this assertion and assessed whether it correlates with D1 dopamine receptor availability, measured using Positron Emission Tomography. We registered response times of 30 older and 30 younger participants during an oddball discrimination task where rewards varied systematically between trials. The average reward rate had a similar impact on vigor in both age groups. There was a weak positive association between ventral striatal dopamine receptor availability and the effect of average reward rate on response time. Overall, the effect of reward on response vigor was similar in younger and older adults, and weakly correlated with dopamine D1 receptor availability.
| Type: | Article |
|---|---|
| Title: | Dopamine and reward-related vigor in younger and older adults |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neurobiolaging.2022.06.003 |
| Publisher version: | https://doi.org/10.1016/j.neurobiolaging.2022.06.0... |
| Language: | English |
| Additional information: | © 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
| Keywords: | Geriatrics & Gerontology, Neurosciences, Neurosciences & Neurology, Vigor, Reward, Dopamine, Aging, NUCLEUS-ACCUMBENS DOPAMINE, DECISION-MAKING, INDIVIDUAL-DIFFERENCES, RATIO REQUIREMENTS, D-AMPHETAMINE, TIME, RECEPTORS, REINFORCEMENT, BEHAVIOR, ACTIVATION |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10155544 |
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