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3D Printed Tetrakis(triphenylphosphine)palladium (0) Impregnated Stirrer Devices for Suzuki-Miyaura Cross-Coupling Reactions

Penny, Matthew R; Rao, Zenobia Xerxes; Thavarajah, Rumintha; Ishaq, Ahtsham; Bowles, Benjamin J; Hilton, Stephen; (2022) 3D Printed Tetrakis(triphenylphosphine)palladium (0) Impregnated Stirrer Devices for Suzuki-Miyaura Cross-Coupling Reactions. Reaction Chemistry & Engineering 10.1039/d2re00218c. (In press). Green open access

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Abstract

3D printed materials can be readily modified to create bespoke structures that incorporate a range of catalysts at the point of printing. In this present study we report on the design and 3D printing of tetrakis (triphenylphosphine) palladium (0) im-pregnated 3D printed stirrer devices that were used to catalyze a Suzuki-Miyaura reaction between biaryl compounds in a batch-based approach. It was shown that the devices themselves are reusable, easy to use, air-stable, give access to an array of biaryl compounds in excellent yields and lead to low levels of palladium loss into the reaction. Simple modification of the device’s design by size reduction, meant that they could also be used to reduce the time of the Suzuki-Miyaura reaction by microwave enhanced heating. At the end of the reaction, devices can simply be removed from the flask, washed and reused, analogous to stirrer bead workflows. This makes the overall process of setting up multiple reactions simpler by obviating the need to weigh out catalysts for reactions and the device, once used, can be simply removed from the reaction media at the end of the reaction.

Type: Article
Title: 3D Printed Tetrakis(triphenylphosphine)palladium (0) Impregnated Stirrer Devices for Suzuki-Miyaura Cross-Coupling Reactions
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/d2re00218c
Publisher version: https://doi.org/10.1039/d2re00218c
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
URI: https://discovery.ucl.ac.uk/id/eprint/10155403
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