UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

2021 WHO classification of tumours of the central nervous system: a review for the neuroradiologist

McNamara, Cillian; Mankad, Kshitij; Thust, Stefanie; Dixon, Luke; Limback-Stanic, Clara; D'Arco, Felice; Jacques, Thomas S; (2022) 2021 WHO classification of tumours of the central nervous system: a review for the neuroradiologist. Neuroradiology , 64 pp. 1919-1950. 10.1007/s00234-022-03008-6. Green open access

[thumbnail of Jacques_Final_after_revision.pdf]
Preview
Text
Jacques_Final_after_revision.pdf

Download (546kB) | Preview

Abstract

The fifth edition of the World Health Organization Classification of Tumours of the Central Nervous System (WHO CNS5) published in 2021 builds on the 2016 edition and incorporates output from the Consortium to Inform Molecular and Practical Approaches to CNS Tumour Taxonomy (cIMPACT-NOW). WHO CNS5 introduces fundamental changes to brain tumour classification through the introduction of new tumour families and types, especially in the paediatric population, and a revision of diagnostic criteria for some of the existing neoplasms. Neuroradiologists are central to brain tumour diagnostics, and it is therefore essential that they become familiar with the key updates. This review aims to summarise the most relevant updates for the neuroradiologist and, where available, discuss the known radiophenotypes of various new tumour types to allow for increased accuracy of language and diagnosis. Of particular importance, WHO CNS5 places greater emphasis on organising tumours by molecular type to reflect biology, as well as to allow for better planning of treatment. The principal updates in adult tumours concern the molecular definition of glioblastoma, restructuring of diffuse gliomas, and the introduction of several new tumour types. The updates to the paediatric classification are protean, ranging from the introduction of new types to establishing separate tumour families for paediatric-type gliomas. This review summarises the most significant revisions and captures the rationale and radiological implications for the major updates.

Type: Article
Title: 2021 WHO classification of tumours of the central nervous system: a review for the neuroradiologist
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00234-022-03008-6
Publisher version: https://doi.org/10.1007/s00234-022-03008-6
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: World Health Organization, Brain tumour, Central nervous system, Classification, Diagnosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10155286
Downloads since deposit
1,196Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item