Mohammadifard, Noushin;
Haghighatdoost, Fahimeh;
Rahimlou, Mehran;
Rodrigues, Ana Paula Santos;
Gaskarei, Mohammadamin Khajavi;
Okhovat, Paria;
de Oliveira, Cesar;
... Sarrafzadegan, Nizal; + view all
(2022)
The Effect of Ketogenic Diet on Shared Risk Factors of Cardiovascular Disease and Cancer.
Nutrients
, 14
(17)
, Article 3499. 10.3390/nu14173499.
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Abstract
Cardiovascular disease (CVD) and cancer are the first and second leading causes of death worldwide, respectively. Epidemiological evidence has demonstrated that the incidence of cancer is elevated in patients with CVD and vice versa. However, these conditions are usually regarded as separate events despite the presence of shared risk factors between both conditions, such as metabolic abnormalities and lifestyle. Cohort studies suggested that controlling for CVD risk factors may have an impact on cancer incidence. Therefore, it could be concluded that interventions that improve CVD and cancer shared risk factors may potentially be effective in preventing and treating both diseases. The ketogenic diet (KD), a low-carbohydrate and high-fat diet, has been widely prescribed in weight loss programs for metabolic abnormalities. Furthermore, recent research has investigated the effects of KD on the treatment of numerous diseases, including CVD and cancer, due to its role in promoting ketolysis, ketogenesis, and modifying many other metabolic pathways with potential favorable health effects. However, there is still great debate regarding prescribing KD in patients either with CVD or cancer. Considering the number of studies on this topic, there is a clear need to summarize potential mechanisms through which KD can improve cardiovascular health and control cell proliferation. In this review, we explained the history of KD, its types, and physiological effects and discussed how it could play a role in CVD and cancer treatment and prevention.
| Type: | Article |
|---|---|
| Title: | The Effect of Ketogenic Diet on Shared Risk Factors of Cardiovascular Disease and Cancer |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/nu14173499 |
| Publisher version: | https://doi.org/10.3390/nu14173499 |
| Language: | English |
| Additional information: | : © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). |
| Keywords: | ketogenic diet; cardiovascular disease; cancer; hypertension; oxidation; inflammation; diabetes; obesity |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10155139 |
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