Liu, Fangqi;
Wu, Yu;
Almarri, Noora;
Habibollahi, Maryam;
Lancashire, Henry T;
Bryson, Barney;
Greensmith, Linda;
... Demosthenous, Andreas; + view all
(2022)
A Fully Implantable Opto-Electro Closed-Loop Neural Interface for Motor Neuron Disease Studies.
IEEE Transactions on Biomedical Circuits and Systems
10.1109/TBCAS.2022.3202026.
(In press).
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Abstract
This paper presents a fully implantable closed-loop device for use in freely moving rodents to investigate new treatments for motor neuron disease. The 0.18 µm CMOS integrated circuit comprises 4 stimulators, each featuring 16 channels for optical and electrical stimulation using arbitrary current waveforms at frequencies from 1.5 Hz to 50 kHz, and a bandwidth programmable front-end for neural recording. The implant uses a Qi wireless inductive link which can deliver >100 mW power at a maximum distance of 2 cm for a freely moving rodent. A backup rechargeable battery can support 10 mA continuous stimulation currents for 2.5 hours in the absence of an inductive power link. The implant is controlled by a graphic user interface with broad programmable parameters via a Bluetooth low energy bidirectional data telemetry link. The encapsulated implant is 40 mm × 20 mm × 10 mm. Measured results are presented showing the electrical performance of the electronics and the packaging method.
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