UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

A Fully Implantable Opto-Electro Closed-Loop Neural Interface for Motor Neuron Disease Studies

Liu, Fangqi; Wu, Yu; Almarri, Noora; Habibollahi, Maryam; Lancashire, Henry T; Bryson, Barney; Greensmith, Linda; ... Demosthenous, Andreas; + view all (2022) A Fully Implantable Opto-Electro Closed-Loop Neural Interface for Motor Neuron Disease Studies. IEEE Transactions on Biomedical Circuits and Systems 10.1109/TBCAS.2022.3202026. (In press). Green open access

[thumbnail of A_Fully_Implantable_Opto-Electro_Closed-Loop_Neural_Interface_for_Motor_Neuron_Disease_Studies.pdf]
Preview
Text
A_Fully_Implantable_Opto-Electro_Closed-Loop_Neural_Interface_for_Motor_Neuron_Disease_Studies.pdf - Accepted Version

Download (18MB) | Preview

Abstract

This paper presents a fully implantable closed-loop device for use in freely moving rodents to investigate new treatments for motor neuron disease. The 0.18 µm CMOS integrated circuit comprises 4 stimulators, each featuring 16 channels for optical and electrical stimulation using arbitrary current waveforms at frequencies from 1.5 Hz to 50 kHz, and a bandwidth programmable front-end for neural recording. The implant uses a Qi wireless inductive link which can deliver >100 mW power at a maximum distance of 2 cm for a freely moving rodent. A backup rechargeable battery can support 10 mA continuous stimulation currents for 2.5 hours in the absence of an inductive power link. The implant is controlled by a graphic user interface with broad programmable parameters via a Bluetooth low energy bidirectional data telemetry link. The encapsulated implant is 40 mm × 20 mm × 10 mm. Measured results are presented showing the electrical performance of the electronics and the packaging method.

Type: Article
Title: A Fully Implantable Opto-Electro Closed-Loop Neural Interface for Motor Neuron Disease Studies
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/TBCAS.2022.3202026
Publisher version: https://doi.org/10.1109/TBCAS.2022.3202026
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Implantable devices, integrated circuits, motor neuron disease, neural recording, opto-electro stimulation, optogenetics
UCL classification: UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/10154835
Downloads since deposit
247Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item