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Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of 'druggable' supramolecular self-associating antimicrobial amphiphiles

Boles, Jessica E; Bennett, Charlotte; Baker, Jennifer; Hilton, Kira LF; Kotak, Hiral A; Clark, Ewan R; Long, Yifan; ... Hiscock, Jennifer R; + view all (2022) Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of 'druggable' supramolecular self-associating antimicrobial amphiphiles. Chemical Science , 2022 (13) pp. 9761-9773. 10.1039/d2sc02630a. Green open access

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Abstract

A combination of computational and synthetic phospholipid vesicle/nanodisc assays are used to investigate the mode of action for a class of antimicrobial agents, while a range of DMPK studies establish agent druggability.

Type: Article
Title: Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of 'druggable' supramolecular self-associating antimicrobial amphiphiles
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/d2sc02630a
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. See: https://creativecommons.org/licenses/by/3.0/
Keywords: Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, DISCOVERY, ENHANCERS, BILAYER, SSAS
UCL classification: UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10154238
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